EMA greenlights second gene therapy

Targeted Gene Therapy of Cancer: Second Amendment toward Holistic Therapy.

It seems solid tumors are developing smart organs with specialized cells creating specified bio-territory, the so called "tumor microenvironment (TME)", in which there is reciprocal crosstalk among cancer cells, immune system cells and stromal cells. TME as an intricate milieu also consists of cancer stem cells (CSCs) that can resist against chemotherapies. In solid tumors, metabolism and vascu...

ژن درمانی Gene Therapy

Cloning and Expression of Immunogenic Regions of EMA-1 Gene of Theileria equi From Infected Horses

Diversity among the pathogenic strains of Theileria equi (T. equi), a major agent of equine piroplasmosis, can affect the appropriate detection of parasite and host immunization. Production of recombinant surface proteins from an infected horse in natural endemic area provides a reliable tool for immunodiagnosis of parasite. Regarding this, the present study was targeted toward the cloning, exp...

EMA - Easy Microarray data Analysis

N. Servant , E. Gravier , P. Gestraud , C. Laurent , C. Paccard , A. Biton , I. Brito , J. Mandel , B. Asselain , E. Barillot , P. Hupé . Institut Curie, Paris F-75248, France, INSERM U900, Paris F-75248, France, Ecole des Mines ParisTech, Fontainebleau, F-77300 France, Institut Curie, Deṕartement de Transfert, Paris F-75248, France, CNRS, UMR144, Paris F-75248, France CNRS, UMR146, Paris F-752...

Recent Advances in Hemophilia Gene Therapy

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...